This is the accompanying repository for publication titled "Receptor Trap in Proteogenomic Mendelian Randomization: How Receptor-Ligand Feedback Loops Give Opposite Directions of Effect." Data used in the analysis will only be made available to approved researchers. The code in this repository is to illustrate the analytical steps and parameters.

Harmonized data serving as the dataset to demo the software/code for Mendelian randomization (MR) can be found in Supplementary Data 3,8,10,13. Expected MR output can be found in Supplementary Data 4,9,11,14 (main analyses) and 5,12,15 (sensitivity analyses).