An oncology toolkit for PacBio HiFi sequencing
Bowhead is an oncology toolkit for PacBio HiFi datasets. Key features include:
- NNLS-based signature decomposition against SBS reference matrices
- Tumor mutational burden with full and defined-base denominators
Authors: Matt Holt, Zev Kronenberg
Please note that Bowhead is still in early development. We are still tweaking the input / output file formats and making changes that can affect the behavior of the program.
Bowhead does not currently have a pre-print or publication.
If you notice any missing features, bugs, or need assistance with analyzing the output of Bowhead, please don't hesitate to open a GitHub issue.
Bowhead is a pre-release software intended for research use only and not for use in diagnostic procedures. While efforts have been made to ensure that Bowhead lives up to the quality that PacBio strives for, we make no warranty regarding this software.
As Bowhead is not covered by any service level agreement or the like, please do not contact a PacBio Field Applications Scientists or PacBio Customer Service for assistance with any Bowhead release. Please report all issues through GitHub instead. We make no warranty that any such issue will be addressed, to any extent or within any time frame.
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