ALZbiomark

Neuroanatomy Correlates of Early Alzheimer's Biomarker; An open Access Multi-Database Secondary Analysis.

Overview

This study aims to systematically map the spatiotemporal relationship between regional nuroanatomical changes and early molecular biomarkers across the preclinical to clinical AD continuum using the NIA-AA AT(N) biomarker framework and the Braak neuropathological staging system. It also seeks to develop predictive models and globally contextualised results using GBD data.

Table of Contents

• Overview
• keywords
• Project Structure
• Data
• Methods
• Results
• Installation
• Usage
• Contributing
• Citation
• License

keywords

Alzheimer's disease, Early biomarkers, Neuroanatomy correlate, Entorihinal cortex, Hippocampal atrophy, P-tau217, ADNI, OASIS, Secondary data analysis

Data

Source

• ADNI
• OASIS-3
• AIBL
• GBD

Prerequisites software

• Python, R, zotero

Installation

git clone https://github.com/FaithEjiofor/-ALZbiomark.git
cd -ALZbiomark
pip install -r requirements.txt