reprodICU Harmonization Validation

Manuscript analyses validating reprodICU harmonization across seven ICU databases using mortality prediction models and cohort comparisons.

Folders

Mortality Prediction/

• 1_cohort.py — Build harmonized cohorts (all 7 databases)
• 1_cohort_from_original_data.py — Build same cohorts from source SQL based on public SQL queries from
  • mimic-code: https://github.com/MIT-LCP/mimic-code
  • eicu-code: https://github.com/MIT-LCP/eicu-code
  • AmsterdamUMCdb: https://github.com/AmsterdamUMC/AmsterdamUMCdb
• 2_models.py — Train LightGBM models; output coefficients and performance metrics
• 3_compare_cohorts.py — Leave-one-database-out cross-validation

General Plots/

• 1_plots.py — Cohort characteristics and missingness patterns
• 2_sofa_subscores.py — SOFA component prevalence analysis