diff --git a/packages/adapter-pg/package.json b/packages/adapter-pg/package.json
index 18c99696018f..2440e6b6b993 100644
--- a/packages/adapter-pg/package.json
+++ b/packages/adapter-pg/package.json
@@ -37,6 +37,7 @@
   "sideEffects": false,
   "dependencies": {
     "@prisma/driver-adapter-utils": "workspace:*",
+    "async-mutex": "0.5.0",
     "pg": "^8.16.3",
     "postgres-array": "3.0.4",
     "@types/pg": "^8.16.0"
diff --git a/packages/adapter-pg/src/__tests__/pg.test.ts b/packages/adapter-pg/src/__tests__/pg.test.ts
index 451005039372..7c02f75ec2e0 100644
--- a/packages/adapter-pg/src/__tests__/pg.test.ts
+++ b/packages/adapter-pg/src/__tests__/pg.test.ts
@@ -134,6 +134,64 @@ describe('PrismaPgAdapterFactory', () => {
     await adapter.dispose()
   })
 
+  it('should serialize concurrent queries within a transaction', async () => {
+    const config: pg.PoolConfig = { user: 'test', password: 'test', database: 'test', port: 5432, host: 'localhost' }
+    const factory = new PrismaPgAdapterFactory(config)
+    const adapter = await factory.connect()
+
+    let inFlight = 0
+    let maxInFlight = 0
+    const mockConnection = {
+      on: vi.fn(),
+      removeListener: vi.fn(),
+      query: vi.fn(async () => {
+        inFlight++
+        maxInFlight = Math.max(maxInFlight, inFlight)
+        await new Promise((resolve) => setTimeout(resolve, 10))
+        inFlight--
+        return { rows: [], fields: [], rowCount: 0 }
+      }),
+      release: vi.fn(),
+      listenerCount: vi.fn().mockReturnValue(0),
+    }
+    adapter['client'].connect = vi.fn().mockResolvedValue(mockConnection)
+
+    const transaction = await adapter.startTransaction()
+    const query: SqlQuery = { sql: 'SELECT 1', args: [], argTypes: [] }
+    await Promise.all([transaction.queryRaw(query), transaction.queryRaw(query), transaction.queryRaw(query)])
+
+    expect(maxInFlight).toBe(1)
+    expect(mockConnection.query).toHaveBeenCalledTimes(4) // BEGIN + 3 queries
+
+    await transaction.commit()
+    await adapter.dispose()
+  })
+
+  it('should release the transaction mutex when a query fails', async () => {
+    const config: pg.PoolConfig = { user: 'test', password: 'test', database: 'test', port: 5432, host: 'localhost' }
+    const factory = new PrismaPgAdapterFactory(config)
+    const adapter = await factory.connect()
+
+    const mockConnection = {
+      on: vi.fn(),
+      removeListener: vi.fn(),
+      query: vi.fn().mockResolvedValue({ rows: [], fields: [], rowCount: 0 }),
+      release: vi.fn(),
+      listenerCount: vi.fn().mockReturnValue(0),
+    }
+    adapter['client'].connect = vi.fn().mockResolvedValue(mockConnection)
+
+    const transaction = await adapter.startTransaction()
+    mockConnection.query.mockRejectedValueOnce(new Error('boom'))
+
+    const query: SqlQuery = { sql: 'SELECT 1', args: [], argTypes: [] }
+    await expect(transaction.queryRaw(query)).rejects.toThrow()
+    await expect(transaction.queryRaw(query)).resolves.toBeDefined()
+
+    await transaction.rollback()
+    await adapter.dispose()
+  })
+
   it('should not pass name when statement name generator is not provided', async () => {
     const factory = new PrismaPgAdapterFactory('postgresql://test:test@localhost/test')
     const adapter = await factory.connect()
diff --git a/packages/adapter-pg/src/pg.ts b/packages/adapter-pg/src/pg.ts
index 6a677bdad614..5a0775dfe604 100644
--- a/packages/adapter-pg/src/pg.ts
+++ b/packages/adapter-pg/src/pg.ts
@@ -13,6 +13,7 @@ import type {
   TransactionOptions,
 } from '@prisma/driver-adapter-utils'
 import { Debug, DriverAdapterError } from '@prisma/driver-adapter-utils'
+import { Mutex } from 'async-mutex'
 // @ts-ignore: this is used to avoid the `Module '"<path>/node_modules/@types/pg/index"' has no default export.` error.
 import pg from 'pg'
 
@@ -98,7 +99,7 @@ class PgQueryable<ClientT extends StdClient | TransactionClient> implements SqlQ
    * Should the query fail due to a connection error, the connection is
    * marked as unhealthy.
    */
-  private async performIO(query: SqlQuery): Promise<pg.QueryArrayResult<any>> {
+  protected async performIO(query: SqlQuery): Promise<pg.QueryArrayResult<any>> {
     const { sql, args } = query
     const values = args.map((arg, i) => mapArg(arg, query.argTypes[i]))
 
@@ -132,6 +133,10 @@ class PgQueryable<ClientT extends StdClient | TransactionClient> implements SqlQ
 }
 
 class PgTransaction extends PgQueryable<TransactionClient> implements Transaction {
+  // pg.PoolClient does not support concurrent queries on the same connection,
+  // so we serialize all performIO calls with a mutex.
+  #mutex = new Mutex()
+
   constructor(
     client: pg.PoolClient,
     readonly options: TransactionOptions,
@@ -141,6 +146,10 @@ class PgTransaction extends PgQueryable<TransactionClient> implements Transactio
     super(client, pgOptions)
   }
 
+  protected async performIO(query: SqlQuery): Promise<pg.QueryArrayResult<any>> {
+    return this.#mutex.runExclusive(() => super.performIO(query))
+  }
+
   async commit(): Promise<void> {
     debug(`[js::commit]`)
 
diff --git a/pnpm-lock.yaml b/pnpm-lock.yaml
index 329dc31e3b16..7f46d3c62985 100644
--- a/pnpm-lock.yaml
+++ b/pnpm-lock.yaml
@@ -315,6 +315,9 @@ importers:
       '@types/pg':
         specifier: ^8.16.0
         version: 8.20.0
+      async-mutex:
+        specifier: 0.5.0
+        version: 0.5.0
       pg:
         specifier: ^8.16.3
         version: 8.16.3