We have mappings to mitochondrial matrix
Claude says:
Ornithine aminotransferase (OAT, EC 2.6.1.13) acts in the mitochondrial matrix.
The enzyme is nuclear-encoded, translated in the cytosol with an N-terminal targeting presequence, and imported into mitochondria, where the presequence is cleaved and the mature protein assembles as a homohexamer in the matrix. That location makes sense functionally — it sits alongside the ornithine/proline interconversion and urea-cycle machinery, using PLP to transfer the δ-amino group of ornithine to 2-oxoglutarate, yielding glutamate-5-semialdehyde (which cyclizes to P5C) and glutamate.
Although SGD annotates as cytosolic based on a single paper.
This needs checking becasue it could be different but mitochondria matrix might
We have mappings to mitochondrial matrix
Claude says:
Ornithine aminotransferase (OAT, EC 2.6.1.13) acts in the mitochondrial matrix.
The enzyme is nuclear-encoded, translated in the cytosol with an N-terminal targeting presequence, and imported into mitochondria, where the presequence is cleaved and the mature protein assembles as a homohexamer in the matrix. That location makes sense functionally — it sits alongside the ornithine/proline interconversion and urea-cycle machinery, using PLP to transfer the δ-amino group of ornithine to 2-oxoglutarate, yielding glutamate-5-semialdehyde (which cyclizes to P5C) and glutamate.
Although SGD annotates as cytosolic based on a single paper.
This needs checking becasue it could be different but mitochondria matrix might