http://pubmed.ncbi.nlm.nih.gov/42412609/
misfolded O-mannosylated ER proteins
targeting to ERAD
so this, will be a) a branch point to ERAD
and b) It seems to act directly downstream of pbn1/gpi14 complex
but presumably this is a separate QC pathway to the GPI biosynthesis (unless the model is incorrect)
"O-mannosylation of misfolded endoplasmic reticulum (ER) proteins in Saccharomyces cerevisiae by the bifunctional O-mannosyltransferase complex Pbn1-Gpi14 generates signals for ER-associated degradation (ERAD), but how these signals are recognized remains unknown."
http://pubmed.ncbi.nlm.nih.gov/42412609/
misfolded O-mannosylated ER proteins
targeting to ERAD
so this, will be a) a branch point to ERAD
and b) It seems to act directly downstream of pbn1/gpi14 complex
but presumably this is a separate QC pathway to the GPI biosynthesis (unless the model is incorrect)
"O-mannosylation of misfolded endoplasmic reticulum (ER) proteins in Saccharomyces cerevisiae by the bifunctional O-mannosyltransferase complex Pbn1-Gpi14 generates signals for ER-associated degradation (ERAD), but how these signals are recognized remains unknown."