diff --git a/ext/dapr-ext-grpc/dapr/ext/grpc/_servicer.py b/ext/dapr-ext-grpc/dapr/ext/grpc/_servicer.py
index a729fab8e..9694e1c53 100644
--- a/ext/dapr-ext-grpc/dapr/ext/grpc/_servicer.py
+++ b/ext/dapr-ext-grpc/dapr/ext/grpc/_servicer.py
@@ -81,6 +81,25 @@ def __init__(self):
         self._registered_topics: List[appcallback_v1.TopicSubscription] = []
         self._registered_bindings: List[str] = []
 
+        self._route_map: Dict[Tuple[str, str], TopicSubscribeCallable] = {}
+        self._validation_disabled_pubsubs: Dict[str, TopicSubscribeCallable] = {}
+
+    def _get_topic_callback(
+        self, pubsub_name: str, topic: str, path: str
+    ) -> Optional[TopicSubscribeCallable]:
+        pubsub_topic = pubsub_name + DELIMITER + topic + DELIMITER + path
+        if pubsub_topic in self._topic_map:
+            return self._topic_map[pubsub_topic]
+
+        if (pubsub_name, path) in self._route_map:
+            return self._route_map[(pubsub_name, path)]
+
+        if path == '':
+            if pubsub_name in self._validation_disabled_pubsubs:
+                return self._validation_disabled_pubsubs[pubsub_name]
+
+        return None
+
     def register_method(self, method: str, cb: InvokeMethodCallable) -> None:
         """Registers method for service invocation."""
         if method in self._invoke_method_map:
@@ -98,10 +117,7 @@ def register_topic(
         disable_topic_validation: Optional[bool] = False,
     ) -> None:
         """Registers topic subscription for pubsub."""
-        if not disable_topic_validation:
-            topic_key = pubsub_name + DELIMITER + topic
-        else:
-            topic_key = pubsub_name
+        topic_key = pubsub_name + DELIMITER + topic
         pubsub_topic = topic_key + DELIMITER
         if rule is not None:
             path = getattr(cb, '__name__', rule.match)
@@ -109,6 +125,10 @@ def register_topic(
         if pubsub_topic in self._topic_map:
             raise ValueError(f'{topic} is already registered with {pubsub_name}')
         self._topic_map[pubsub_topic] = cb
+        self._route_map[(pubsub_name, topic)] = cb
+
+        if disable_topic_validation:
+            self._validation_disabled_pubsubs[pubsub_name] = cb
 
         registered_topic = self._registered_topics_map.get(topic_key)
         sub: appcallback_v1.TopicSubscription = appcallback_v1.TopicSubscription()
@@ -196,15 +216,10 @@ def ListTopicSubscriptions(self, request, context):
 
     def OnTopicEvent(self, request: TopicEventRequest, context):
         """Subscribes events from Pubsub."""
-        pubsub_topic = request.pubsub_name + DELIMITER + request.topic + DELIMITER + request.path
-        no_validation_key = request.pubsub_name + DELIMITER + request.path
-
-        if pubsub_topic not in self._topic_map:
-            if no_validation_key in self._topic_map:
-                pubsub_topic = no_validation_key
-            else:
-                context.set_code(grpc.StatusCode.UNIMPLEMENTED)  # type: ignore
-                raise NotImplementedError(f'topic {request.topic} is not implemented!')
+        cb = self._get_topic_callback(request.pubsub_name, request.topic, request.path)
+        if cb is None:
+            context.set_code(grpc.StatusCode.UNIMPLEMENTED)  # type: ignore
+            raise NotImplementedError(f'topic {request.topic} is not implemented!')
 
         customdata: Struct = request.extensions
         extensions = dict()
@@ -222,7 +237,7 @@ def OnTopicEvent(self, request: TopicEventRequest, context):
         event.SetSubject(request.topic)
         event.SetExtensions(extensions)
 
-        response = self._topic_map[pubsub_topic](event)
+        response = cb(event)
         if isinstance(response, TopicEventResponse):
             return appcallback_v1.TopicEventResponse(status=response.status.value)
         return empty_pb2.Empty()
@@ -292,15 +307,10 @@ def _handle_bulk_topic_event(
         self, request: TopicEventBulkRequest, context
     ) -> Optional[TopicEventBulkResponse]:
         """Process bulk topic event request - routes each entry to the appropriate topic handler."""
-        topic_key = request.pubsub_name + DELIMITER + request.topic + DELIMITER + request.path
-        no_validation_key = request.pubsub_name + DELIMITER + request.path
-
-        if topic_key not in self._topic_map and no_validation_key not in self._topic_map:
+        cb = self._get_topic_callback(request.pubsub_name, request.topic, request.path)
+        if cb is None:
             return None  # we don't have a handler
 
-        handler_key = topic_key if topic_key in self._topic_map else no_validation_key
-        cb = self._topic_map[handler_key]  # callback
-
         statuses = []
         for entry in request.entries:
             entry_id = entry.entry_id
diff --git a/ext/dapr-ext-grpc/tests/test_servicier.py b/ext/dapr-ext-grpc/tests/test_servicier.py
index 1fe18c5dc..ff6910ee0 100644
--- a/ext/dapr-ext-grpc/tests/test_servicier.py
+++ b/ext/dapr-ext-grpc/tests/test_servicier.py
@@ -182,6 +182,40 @@ def test_non_registered_topic(self):
                 self.fake_context,
             )
 
+    def test_multiple_wildcard_subscriptions(self):
+        self._servicer.register_topic(
+            'pubsub_multi_wildcard',
+            'orders/+/items',
+            self._topic1_method,
+            None,
+            disable_topic_validation=True,
+        )
+        self._servicer.register_topic(
+            'pubsub_multi_wildcard',
+            'inventory/#',
+            self._topic2_method,
+            None,
+            disable_topic_validation=True,
+        )
+
+        self._servicer.OnTopicEvent(
+            appcallback_v1.TopicEventRequest(
+                pubsub_name='pubsub_multi_wildcard', topic='orders/123/items', path='orders/+/items'
+            ),
+            self.fake_context,
+        )
+        self._topic1_method.assert_called_once()
+
+        self._servicer.OnTopicEvent(
+            appcallback_v1.TopicEventRequest(
+                pubsub_name='pubsub_multi_wildcard',
+                topic='inventory/warehouse/aisle4',
+                path='inventory/#',
+            ),
+            self.fake_context,
+        )
+        self._topic2_method.assert_called_once()
+
 
 class BulkTopicEventTests(unittest.TestCase):
     def setUp(self):