My understanding is that the variation normalizer is restricted to support variants described on GRCh37/38, but it appears to currently support some variant types on NCBI 36 too.
{
"warnings": [],
"service_meta_": {
"name": "variation-normalizer",
"version": "0.15.0",
"response_datetime": "2025-08-07T16:22:55.444722Z",
"url": "https://github.com/cancervariants/variation-normalization"
},
"variation_query": "NC_000005.8:g.123452G>C",
"variation": {
"id": "ga4gh:VA.ZWdCwi4D4nKN9CpkDliDnPgyAJk5bEdb",
"type": "Allele",
"digest": "ZWdCwi4D4nKN9CpkDliDnPgyAJk5bEdb",
"location": {
"id": "ga4gh:SL._pFs_WVxZOf3ta0S2unYUuOdrsJom1JL",
"type": "SequenceLocation",
"digest": "_pFs_WVxZOf3ta0S2unYUuOdrsJom1JL",
"sequenceReference": {
"type": "SequenceReference",
"refgetAccession": "SQ.sphQQhTwLddZFu6ZmSQIR9k0FR4n_B5Z"
},
"start": 123451,
"end": 123452,
"sequence": "G"
},
"state": {
"type": "LiteralSequenceExpression",
"sequence": "C"
}
}
}
A warning message would be returned reporting that variants on NCBI 36 are not supported. The returned variant would be described on the NCBI 36 reference sequence.
Describe the bug
My understanding is that the variation normalizer is restricted to support variants described on GRCh37/38, but it appears to currently support some variant types on NCBI 36 too.
Steps to reproduce
Expected behavior
A warning message would be returned reporting that variants on NCBI 36 are not supported. The returned variant would be described on the NCBI 36 reference sequence.
Current behavior
See steps to reproduce
Possible reason(s)
No response
Suggested fix
No response
Branch, commit, and/or version
branch: staging
Screenshots
No response
Environment details
Mac M4
Additional details
No response
Contribution
None