diff --git a/aur/PKGBUILD b/aur/PKGBUILD
index 42c516bd..08249b3d 100644
--- a/aur/PKGBUILD
+++ b/aur/PKGBUILD
@@ -33,7 +33,7 @@ provides=('rdc-cli')
 conflicts=('rdc-cli')
 source=(
   "git+https://github.com/BANANASJIM/rdc-cli.git"
-  "git+https://github.com/baldurk/renderdoc.git#tag=v1.41"
+  "git+https://github.com/baldurk/renderdoc.git#tag=v1.46"
   "renderdoc-swig::https://github.com/baldurk/swig/archive/renderdoc-modified-7.zip"
 )
 sha256sums=('SKIP'
diff --git a/aur/stable/PKGBUILD b/aur/stable/PKGBUILD
index 349be067..cd732a7d 100644
--- a/aur/stable/PKGBUILD
+++ b/aur/stable/PKGBUILD
@@ -33,7 +33,7 @@ provides=('rdc-cli')
 conflicts=('rdc-cli-git')
 source=(
   "rdc-cli-${pkgver}.tar.gz::https://github.com/BANANASJIM/rdc-cli/archive/refs/tags/v${pkgver}.tar.gz"
-  "git+https://github.com/baldurk/renderdoc.git#tag=v1.41"
+  "git+https://github.com/baldurk/renderdoc.git#tag=v1.46"
   "renderdoc-swig::https://github.com/baldurk/swig/archive/renderdoc-modified-7.zip"
 )
 sha256sums=('PLACEHOLDER'
diff --git a/docker/Dockerfile b/docker/Dockerfile
index 434fd834..3a3d14db 100644
--- a/docker/Dockerfile
+++ b/docker/Dockerfile
@@ -17,7 +17,7 @@ RUN apt-get update && apt-get install -y --no-install-recommends \
     && rm -rf /var/lib/apt/lists/*
 
 # Build renderdoc from source with Python module enabled
-ARG RENDERDOC_VERSION=v1.41
+ARG RENDERDOC_VERSION=v1.46
 RUN git clone --depth 1 --branch ${RENDERDOC_VERSION} \
         https://github.com/baldurk/renderdoc.git /renderdoc \
     && cd /renderdoc \
diff --git a/scripts/build-renderdoc.sh b/scripts/build-renderdoc.sh
index 0edbe5d3..3727cfb4 100755
--- a/scripts/build-renderdoc.sh
+++ b/scripts/build-renderdoc.sh
@@ -1,12 +1,12 @@
 #!/usr/bin/env bash
 # DEPRECATED: use scripts/build_renderdoc.py instead.
 # Kept for curl-pipe users on systems without Python 3.10+.
-# Build renderdoc v1.41 Python module from source.
+# Build renderdoc v1.46 Python module from source.
 # Usage: bash <(curl -fsSL https://raw.githubusercontent.com/BANANASJIM/rdc-cli/master/scripts/build-renderdoc.sh) [INSTALL_DIR]
 # Output: INSTALL_DIR/renderdoc.so + librenderdoc.so (default: ~/.local/renderdoc/)
 set -euo pipefail
 
-RDOC_TAG="v1.41"
+RDOC_TAG="v1.46"
 SWIG_URL="https://github.com/baldurk/swig/archive/renderdoc-modified-7.zip"
 SWIG_SHA256="9d7e5013ada6c42ec95ab167a34db52c1cc8c09b89c8e9373631b1f10596c648"
 OUT_DIR="${1:-${HOME}/.local/renderdoc}"
diff --git a/scripts/setup-renderdoc.sh b/scripts/setup-renderdoc.sh
index 92e16d59..df0b1da5 100755
--- a/scripts/setup-renderdoc.sh
+++ b/scripts/setup-renderdoc.sh
@@ -1,13 +1,13 @@
 #!/usr/bin/env bash
 # DEPRECATED: use scripts/build_renderdoc.py instead.
 # Kept for curl-pipe users on systems without Python 3.10+.
-# Build renderdoc v1.41 Python module for the pixi dev environment.
+# Build renderdoc v1.46 Python module for the pixi dev environment.
 # Usage: pixi run setup-renderdoc
 # Output: .local/renderdoc/renderdoc.so + librenderdoc.so
 # Only needs to run once (or after Python version change).
 set -euo pipefail
 
-RDOC_TAG="v1.41"
+RDOC_TAG="v1.46"
 SWIG_URL="https://github.com/baldurk/swig/archive/renderdoc-modified-7.zip"
 BUILD_DIR=".local/renderdoc-build"
 OUT_DIR=".local/renderdoc"
diff --git a/src/rdc/_build_renderdoc.py b/src/rdc/_build_renderdoc.py
index 9d8c36c7..9b6f4bb5 100644
--- a/src/rdc/_build_renderdoc.py
+++ b/src/rdc/_build_renderdoc.py
@@ -30,7 +30,7 @@
 from pathlib import Path
 from urllib.request import urlretrieve
 
-RDOC_TAG = "v1.41"
+RDOC_TAG = "v1.46"
 RDOC_REPO = "https://github.com/baldurk/renderdoc.git"
 SWIG_URL = "https://github.com/baldurk/swig/archive/renderdoc-modified-7.zip"
 SWIG_SHA256 = "9d7e5013ada6c42ec95ab167a34db52c1cc8c09b89c8e9373631b1f10596c648"
@@ -258,7 +258,8 @@ def _run_msbuild(build_dir: Path, python_prefix: Path, jobs: int | None = None)
     msbuild = _find_msbuild()
     n = jobs or os.cpu_count() or 4
     env = dict(os.environ)
-    env["RENDERDOC_PYTHON_PREFIX64"] = str(python_prefix)
+    env["RENDERDOC_PYTHON_PREFIX64"] = str(python_prefix)  # RenderDoc <= v1.41
+    env["VSPythonOverridePath"] = str(python_prefix)  # RenderDoc >= v1.46
     env["CL"] = (env.get("CL", "") + " /wd4996").strip()
     cmd = [
         msbuild,
diff --git a/tests/unit/test_build_renderdoc.py b/tests/unit/test_build_renderdoc.py
index fa3b61d6..2bedc774 100644
--- a/tests/unit/test_build_renderdoc.py
+++ b/tests/unit/test_build_renderdoc.py
@@ -149,7 +149,7 @@ def test_clone_renderdoc_fresh(tmp_path: Path) -> None:
     assert "--depth" in args
     assert "1" in args
     assert "--branch" in args
-    assert "v1.41" in args
+    assert "v1.46" in args
 
 
 def test_clone_renderdoc_idempotent(tmp_path: Path) -> None:
diff --git a/tests/unit/test_tooling_files.py b/tests/unit/test_tooling_files.py
index aaf83656..5c753e61 100644
--- a/tests/unit/test_tooling_files.py
+++ b/tests/unit/test_tooling_files.py
@@ -37,7 +37,7 @@ def test_build_renderdoc_script_syntax() -> None:
 def test_build_renderdoc_script_constants() -> None:
     text = Path("scripts/build-renderdoc.sh").read_text()
     assert "set -euo pipefail" in text
-    assert "v1.41" in text
+    assert "v1.46" in text
     assert "9d7e5013" in text
     assert "RENDERDOC_PYTHON_PATH" in text
     assert "DRENDERDOC_SWIG_PACKAGE" in text